SALNAMELERE GÖRE ANTAKYA KAZASI NDA EĞİTİM (H. 1316-1326/ M. 1898-1908)

NDA-I1: NDA Approval Letter

CLINICAL PHARMACOLOGY Absorption After oral administration, tinidazole is rapidly and completely absorbed. A bioavailability study of Tindamax tablets was conducted in adult healthy volunteers. All subjects received a single oral dose of 2 g (four 500 mg tablets) of tinidazole following an overnight fast. Oral administration of four 500 mg tablets of Tindamax under fasted conditions produced a ...

Dmd058073 1326..1333

Lenvatinib is a multityrosine kinase inhibitor that inhibits vascular endothelial growth factor receptors, and is being developed as an anticancer drug. P450s are involved in one of the elimination pathways of lenvatinib, and mono-oxidized metabolites, such as N-oxide (M3) and desmethylated metabolite (M2), form in rats, dogs, monkeys, and humans. Meanwhile, two other oxidative metabolites are ...

John H. Knox, 1898-1979: a brief biography.

Dmd065201 1316..1325

Several nuclear receptor (NR) superfamily members are known to be the molecular target of either the small ubiquitin-related modifier (SUMO) or ubiquitin-signaling pathways. However, little is currently known regarding how these two post-translational modifications interact to control NR biology. We show that SUMO and ubiquitin circuitry coordinately modifies the pregnane X receptor (PXR, NR1I2...

An 1326 Application Note

Over the past two decades plenty of resonant and quasi-resonant converters have been developed and proposed as an answer to the difficulties raised by square-wave converters, especially those related to their parasitic elements. The basic idea is to put these parasitics in use. The core of both classes of converters is a tank circuit. Unlike resonant converters, where it takes part actively in ...